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A major cause of aging is the deterioration of the energy-producing
components of the cell, which results in reduced cellular metabolic
activity, the accumulation of cellular debris, and eventual death of
the cell. L-carnitine helps to maintain cellular energy
metabolism by assisting in the transport of fat through the cell
membrane and into the mitochondria within the cell, where these fats
are oxidized to produce the cellular energy ATP.
Acetyl-L-carnitine is the acetylated ester of the amino acid
L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane
compound that helps to maintain mitochondrial bioenergetics and lowers
the increased oxidative stress associated with aging.14
Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream
efficiently and both are very effective at carrying fatty acids across
the membrane into the cell where they are burned as energy and utilized
efficiently in the mitochondria of the cell.15,16 Acetyl-L-carnitine
also guards against oxidative damage.17 Amyloid-beta peptide is a
principal component of senile plaques and is thought to be central to
the pathogenesis of degenerating process.
Acetyl-L-carnitine exerts protective effects against Abeta neurotoxicity and oxidative stress.
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